US Surgeons Perform First Pig-to-Human Kidney Transplant

In an unprecedented medical feat, the surgeon Massachusetts General Hospital in Boston first performed kidney transplant from pig to human, A 62 year old man with end stage renal disease received a new kidney from genetically modified pig,

Importance and interest in long-term outcomes

Experts have keen interest in this long term results of this pioneer animal to human transplant, Dr. Jim Kim, Director of Kidney and Pancreas Transplantation USC Transplant Institute in Los AngelesHighlighted the importance of this milestone.

Recipient’s medical history

The recipient, whose name has not been disclosed, had previously received a human kidney transplant In the same hospital in 2018 after being on dialysis for seven years. However, the organ failed after five years, and he had to start over. dialysis treatment,

genetically modified pig kidney

Transplanted kidney provided by eGenesis, a company based in Cambridge, Massachusetts. Pig from which kidney was removed genetically edited Removing genes harmful to the human recipient and adding some human genes to improve compatibility. Additionally, the company inactivated viruses contained in pigs that could potentially infect humans.

Previous successful transplants in monkeys

Before this human transplant, kidneys from identically edited pigs bred by Eogenesis were successfully transplanted into monkeys. These monkeys lived an average of 176 days, with one case lasting more than two years, according to the researchers’ findings, published in the journal Nature in October 2022.

Immunosuppressive drugs and experimental antibodies

To help prevent rejection of the pig organ by the patient’s immune system, doctors used a combination of immunosuppressant drugs and an experimental antibody called tegoprubaartDeveloped by Aledon Pharmaceuticals.

Progress in xenotransplantation

This marks a significant advancement in the field of surgery. xenotransplantation – Transplantation of organs or tissues from one species to another. Dr. Robert Montgomery, director of the NYU Langone Transplant Institute, who was not involved in the case, said the field is “moving closer to becoming an alternative source of organs for thousands of people suffering from kidney failure.”

Organ shortage and future clinical trials

According to the United Network for Organ Sharing, more than 100,000 people in the US are waiting for an organ for transplant, with kidneys in highest demand. Dr. Montgomery expressed that another important step will be when the FDA authorizes clinical trials to better understand the most effective approach for waitlisted patients.

This unprecedented achievement represents a promising step toward addressing the critical shortage of organs available for transplantation and potentially saving countless lives.

American surgeons perform the first kidney transplant from a pig to a human_40.1

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